Hypovitaminosis D is a common condition with a negative impact on health.This statement, prepared by experts from the Brazilian Society of Endocrinology and Metabolism and the Brazilian Society of Clinical Pathology/Laboratory Medicine, includes methodological aspects and limitations of the measurement of 25-hydroxyvitamin D [25(OH)D] for identification of vitamin D status, and identifies individuals at increased risk for deficiency of this vitamin in whom 25(OH)D measurement is recommended. For the general population, 25(OH)D levels between 20 and 60 ng/mL are considered normal, while individuals with levels below 20 ng/mL are considered to be vitamin D deficient. This statement identifies potential benefits of maintaining 25(OH)D levels > 30 ng/mL in specific conditions, including patients aged > 65 years or pregnant, those with recurrent falls, fragility fractures, osteoporosis, secondary hyperparathyroidism, chronic kidney disease, or cancer, and individuals using drugs with the potential to affect the vitamin D metabolism. This statement also calls attention to the risk of vitamin D intoxication, a life-threatening condition that occurs at 25(OH) D levels above 100 ng/mL.
CITATION STYLE
Moreira, C. A., Ferreira, C. E. D. S., Madeira, M., Carvalho Silva, B. C., Maeda, S. S., Batista, M. C., … Lazaretti-Castro, M. (2020). Reference values of 25-hydroxyvitamin d revisited: A position statement from the brazilian society of endocrinology and metabolism (SBEM) and the Brazilian society of clinical pathology/ laboratory medicine (SBPC). Archives of Endocrinology and Metabolism, 64(4), 462–478. https://doi.org/10.20945/2359-3997000000258
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