Evaluation of the acute and subchronic toxicity of Ziwan Baibu Tang

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Abstract

Background: Ziwan Baibu Tang (ZBT) is used as a traditional Chinese prescription used in the clinic to cure a variety of respiratory diseases. The objective of this study was to evaluate the acute and subacute toxicity of ZBT. Materials and Methods: Fifty Kunming mice were assigned to 5 groups, and ZBT was administered at different concentrations. Symptoms, mortality and behavioural changes were recorded. Eighty Wistar rats were randomly allocated to 4 treatment groups or a control group for 4 weeks of treatment (half male and half female); general observations and weekly body weight (BW) gain were recorded. At the end of the 4-week experiment, the rats were sacrificed, and blood was collected for haematological and serum biochemical analyses. Samples from the primary organs were fixed in 10% buffered formalin for histopathological studies. Results: The calculated LD50 of acute oral toxicity was 319.16 g/kg BW. After the 4-week treatment, BW did not significantly differ in any of the dose groups, compared with the control group (P>0.05), and the rat blood red blood cell (RBC) and haemoglobin (HGB) levels in each dose group did not significantly differ (P>0.05). In addition, serum urea and creatine levels in each dose group did not significantly differ from those in the control group (P>0.05). Conclusion: These results indicate that ZBT does not possess toxic potential and that both the acute and subchronic toxicity in animals are very low.

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Xin, R. H., Peng, W. J., Liu, X. L., Luo, Y. J., Wang, G. B., Luo, C. Y., … Zheng, J. F. (2016). Evaluation of the acute and subchronic toxicity of Ziwan Baibu Tang. African Journal of Traditional, Complementary and Alternative Medicines, 13(3), 140–149. https://doi.org/10.4314/ajtcam.v13i3.17

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