Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. © 2013 Wicherts et al; licensee BioMed Central Ltd.
CITATION STYLE
Wicherts, D. A., van Coevorden, F., Klomp, H. M., van Huizum, M. A., Kerst, J. M., Haas, R. L. M., … van der Hage, J. A. (2013). Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib. World Journal of Surgical Oncology, 11. https://doi.org/10.1186/1477-7819-11-59
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