YY1 and KLF4: Their role 2 in gastrointestinal malignancies

Abstract

Gastrointestinal (GI) malignancies are among the most serious threats to global health and are among the major causes of morbidity and mortality. KLF4 and YY1 occupy a central niche and can influence the process of oncogenesis of the various tissues of the GI tract in a major way by being closely associated with several cellular processes such as cell proliferation, differentiation, DNA repair, epigenetic modifications, and apoptosis. Although evidence over the years has implicated KLF4 and YY1 in the process of tumorigenesis, significant loopholes still remain. This review is an attempt to evaluate the relative contributions of KLF4 and YY1 to various aspects of GI malignancies.