Microtubule-Associated Proteins and Microtubule-Interacting Proteins

Abstract

Microtubules are regulated by a range of proteins that interact with tubulin and regulate their stability. A large number and variety of microtubule-associated proteins (MAPs) and microtubule-interacting proteins have been indentified and they exhibit cell and tissue specific expression. MAPs and microtubule-interacting proteins carry out a wide range of functions including regulation of microtubule stability, cross- linking microtubules and mediate interactions of microtubules with other proteins in the cell. The dynamic nature of microtubules and their range of cellular functions is dependent of the interaction and regulation of MAPs and microtubule-interacting proteins.