A Novel Electrochemical Sensor Based on Conductive Cu3(HITP)2/electrochemical Reduced Graphene Oxide Nanocomposite for Simultaneous Determination of Dopamine and Acetaminophen

Abstract

Monitoring small amount of dopamine (DA) and acetaminophen (ACOP) in biological samples is of great significance for the early prevention of neurological diseases and safe use of medicines in clinical research. A novel electrochemical sensor based on conductive metal organic framework Cu3(HITP)2 (HITP=2,3,6,7,10,11-hexaiminotriphenylene) and electrochemical reduced graphene oxide nanocomposite (denoted as Cu3(HITP)2/ERGO) was designed for simultaneous determination of DA and ACOP with enhanced sensitivity and selectivity. The Cu3(HITP)2/ERGO nanocomposite was characterized by scanning electron microcopy, energy dispersive spectroscopy and Fourier infrared spectroscopy. The oxidation potential separation of DA and ACOP achieved 226 mV. The Cu3(HITP)2/ERGO/GCE exhibited excellent electrochemical response towards the oxidation of DA and ACOP due to the superior conductivity and synergistic catalytic activity of Cu3(HITP)2/ERGO nanocomposite. The detection limits were 9 nM and 14 nM (S/N=3) for DA and ACOP with wide linear range of 0.05-150 μM and 0.1-100 μM, respectively. Furthermore, the proposed sensor has been successfully applied in the simultaneous detection of DA and ACOP in serum sample.