The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

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Abstract

The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

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Lee, K. H., Dinner, A. R., Tu, C., Campi, G., Raychaudhuri, S., Varma, R., … Shaw, A. S. (2003). The Immunological Synapse Balances T Cell Receptor Signaling and Degradation. Science, 302(5648), 1218–1222. https://doi.org/10.1126/science.1086507

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