A mechanism for learning with sleep spindles

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Abstract

Spindles are ubiquitous oscillations during non-rapid eye movement (NREM) sleep. A growing body of evidence points to a possible link with learning and memory, and the underlying mechanisms are now starting to be unveiled. Specifically, spindles are associated with increased dendritic activity and high intracellular calcium levels, a situation favourable to plasticity, as well as with control of spiking output by feed-forward inhibition. During spindles, thalamocortical networks become unresponsive to inputs, thus potentially preventing interference between memory-related internal information processing and extrinsic signals. At the system level, spindles are co-modulated with other major NREM oscillations, including hippocampal sharp wave-ripples (SWRs) and neocortical slow waves, both previously shown to be associated with learning and memory. The sequential occurrence of reactivation at the time of SWRs followed by neuronal plasticity-promoting spindles is a possible mechanism to explain NREM sleep-dependent consolidation of memories. This article is part of the Theo Murphy meeting issue ‘Memory reactivation: replaying events past, present and future’.

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CITATION STYLE

APA

Peyrache, A., & Seibt, J. (2020, May 25). A mechanism for learning with sleep spindles. Philosophical Transactions of the Royal Society B: Biological Sciences. Royal Society Publishing. https://doi.org/10.1098/rstb.2019.0230

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