We investigated the tracking potential of a magnetic resonance imaging (MRI) probe made of gadolinium-doped mesoporous silica MCM-41 (Gd2O3@MCM-41) nanoparticles for transplanted bone mesenchymal stem cells (MSCs) and neural stem cells (NSCs) in vivo. The nanoparticles, synthesized using a one-step synthetic method, possess hexagonal mesoporous structures with appropriate assembly of nanoscale Gd2O3 clusters. They show little cytotoxicity against proliferation and have a lower effect on the inherent differentiation potential of these labeled stem cells. The tracking of labeled NSCs in murine brains was dynamically determined with a clinical 3T MRI system for at least 14 days. The migration of labeled NSCs identified by MRI corresponded to the results of immunofluorescence imaging. Our study confirms that Gd2O3@MCM-41 particles can serve as an ideal vector for long-term MRI tracking of MSCs and NSCs in vivo. © 2013 Shen et al, publisher and licensee Dove Medical Press Ltd.
CITATION STYLE
Shen, Y., Shao, Y., He, H., Tan, Y., Tian, X., Xie, F., & Li, L. (2013). Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo. International Journal of Nanomedicine, 8, 119–127. https://doi.org/10.2147/IJN.S38213
Mendeley helps you to discover research relevant for your work.