Internalization of exosomes through receptor-mediated endocytosis

43Citations
Citations of this article
107Readers
Mendeley users who have this article in their library.

Abstract

The tumor microenvironment is replete with factors secreted and internalized by surrounding cells. Exosomes are nanosized, protein-embedded, membrane-bound vesicles that are released in greater quantities from cancer than normal cells and taken up by a variety of cell types. These vesicles contain proteins and genetic material from the cell of origin and in the case of tumor-derived exosomes, oncoproteins and oncogenes. With increasing understanding of the role exosomes play in basic biology, a more clear view of the potential exosomes are seen to have in cancer therapeutics emerges. However, certain essential aspects of exosome function, such as the uptake mechanisms, are still unknown. Various methods of cell-exosome interaction have been proposed, but this review focuses on the protein-protein interactions that facilitate receptor-mediated endocytosis, a broadly used mechanism by a variety of cells.

Cite

CITATION STYLE

APA

Gonda, A., Kabagwira, J., Senthil, G. N., & Wall, N. R. (2019, February 1). Internalization of exosomes through receptor-mediated endocytosis. Molecular Cancer Research. American Association for Cancer Research Inc. https://doi.org/10.1158/1541-7786.MCR-18-0891

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free