Assessment of acute and subchronic oral toxicity of ethanolic extract of Pothomorphe umbellata L. Miq. (Pariparoba)

Abstract

There is a high degree of concern regarding the secure use of plant extracts and, for this very reason, preclinical and clinic toxicological evaluation of these extracts are needed. With the aim to assure the quality and the safety of the extract and due to the scarcity of literature information about Pariparoba extract toxicity, our purpose was to investigate the acute and subchronic toxicity of the standardized ethanolic dried root extract of Pothomorphe umbellata L. Miq. This extract was administered orally to adult swiss mice and wistar rats and the mutagenic potential of the extract was also evaluated. The extract showed to be non toxic.