Cyclovirobuxine

Abstract

Cyclovirobuxine is an alkaloid extracted from common boxwood (Buxus microphylla Sieb. et Zucc. var. sinica Rehd. et Wils) and its genus. Its chemical structure is a derivative of pregnane. Cyclovirobuxine is a new Chinese medicine that is successfully developed for the treatment of cardiovascular diseases in recent years. After decades of clinical observation, cyclovirobuxine has the therapeutic role of anti-myocardial ischemia and antiarrhythmia and protects against acute cerebral ischemia. In addition, cyclovirobuxine can cross the blood-brain barrier and improve brain microcirculation and oxygen supply to treat cerebral arteriosclerosis insufficiency. In all, it has potent curative effects and low risk of side effects. The safety of oral administration of cyclovirobuxine is excellent, while the risk of side effects in long-term use is low, which indicates that this drug has a good application prospect.