Oxidative Stress in Diabetes Mellitus and Possible Interventions

Abstract

A substantial amount of evidence has demonstrated that diabetes is highly associated with oxidative stress. The unifying theory that hyperglycemia-induced elevations in superoxide production underlie the activation of many pathways involved in the onset, progression, and pathological consequences of diabetes naturally raised an interest in the role of antioxidant treatment. In this chapter, after analyzing the molecular mechanisms of the excessive oxidative stress in diabetes, we will discuss the potential therapeutic interventions including pharmaceutical agents, diet, and exercise.