The signaling cascade of most adhesion-GPCRs remains uncharacterized, as the majority are still orphan receptors and further complicated by their unique structure containing a cleaved long extracellular domain (ECD) and a seven-transmembrane domain (7TM). In this chapter, we review previous reports which suggest G protein-dependent and -independent signaling pathways of adhesion-GPCRs and present our approach to investigate the signal transduction of the adhesion-GPCR, GPR56. © 2010 Landes Bioscience and Springer Science+Business Media, LLC.
CITATION STYLE
Mizuno, N., & Itoh, H. (2010). Signal transduction mediated through adhesion-GPCRs. Advances in Experimental Medicine and Biology, 706, 157–166. https://doi.org/10.1007/978-1-4419-7913-1_14
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