The effect of catabolic doses of corticosterone on heat production in the growing rat

Abstract

1. The effect of corticosterone treatment on energy balance and heat production was investigated in growing rats. Animals were treated with daily subcutaneous injections of a vehicle containing 0, 50 or 100 mg corticosterone/kg for 5 d.2. Measurements of digestible energy intake and urinary energy losses showed that corticosterone treatment resulted in a depression of metabolizable energy intake due to elevated urinary energy losses resulting from massive glucosuria.3. Measurements of the metabolizable energy intake and the change in carcass energy indicated that at 50 mg/kg energy deposition and heat production were reduced, whilst at 100 mg/kg energy deposition was completely abolished with heat production increased. Postprandial oxygen consumption was unchanged at 50 mg/kg and increased at 100 mg/kg.4. Factorial analysis of these results based on reported values for the energy cost of protein and fat deposition indicated that (a) the depression of total heat production at 50 mg/kg could be entirely accounted for by the concomitant suppression of growth, and (b) the elevation of total and postprandial heat production at 100 mg/kg reflected a specific influence of corticosterone on thermogenesis.5. The significance of these findings is discussed in the light of reports that corticosterone in low doses suppresses heat production.