Strategies in the development of new drugs and drug combinations against leprosy, demonstrated on the example of folate and gyrase inhibitors

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Abstract

The position of the modern medical chemist in comparison to his predecessor, who had to face these problems 20 years ago, is much more favourable. With methods, which will be discussed in a relation to a few selected examples, it is possible to speed up the optimization of lead compounds within a congeneric set of derivatives, to detect and quantify outliers and to gain information on the mechanism of action.

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APA

Seydel, J. K., Rosenfeld, M., Sathish, M., Wiese, M., Schaper, K. J., Hachtel, G., … Dhople, A. M. (1986). Strategies in the development of new drugs and drug combinations against leprosy, demonstrated on the example of folate and gyrase inhibitors. Leprosy Review, 57(SUPPL. 3), 235–253. https://doi.org/10.5935/0305-7518.19860114

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