Hysteresis of the cerebrospinal pressure-volume curve in hydrocephalus

Abstract

The objective was to study the displacement of the cerebrospinal fluid pressure-volume curve during the descent relative to the ascent of intracranial pressure recorded during the cerebrospinal fluid constant rate infusion test. This phenomenon can be interpreted as the hysteresis of the pressure-volume curve. The cerebrospinal fluid dynamics were tested in fifty-eight patients with clinical symptoms of hydrocephalus. After finished infusion, ICP was recorded until it returned to steady state level. Pressure- volume curves were plotted separately for ascending and descending phases of the test. The parameters of CSF compensation were estimated on the basis of mathematical mono-exponential model of CSF circulation. The pressure-volume curve post-infusion was visibly shifted upward in 69% of tests. Those who demonstrated the upward shift of the pressure-volume curve had greater an elastance coefficient of the cerebrospinal space (with shift: E1 =0.26 ± 0.14; without shift: E1 = 0.17 ± 0.06; p < 0.05). Magnitude of the shift was positively correlated with pulse amplitude of ICP (r = -0.763; p < 0.0001). The accuracy of clinical examination of the pressure-volume compensatory reserve, which take into account both compression and decompression phase of the study, may be affected by this phenomenon. © Spnnger-Verlag 2003.