Skin-Layer Analysis Using Optical Coherence Tomography (OCT)

Abstract

In the past decade, advances in optics, fiber as well as laser technology, have enabled development of a novel noninvasive optical biomedical imaging technique, optical coherence tomography (OCT). Optical coherence tomography (OCT) is a micrometer scale, noninvasive, nondestructive, cross-sectional optical imaging technique for use in biological systems. It is an interferometric technique with a low coherence light source, typically using near-infrared light, which enables deep penetration into the scattering medium without damage to the human body. It has become a prominent imaging technique for precision measurement in various applications, including diagnosis in the medical field. Investigations using OCT to assess skin structure in clinical settings started in the past decade and consequently proved that this imaging method is useful in visualizing subsurface structures of normal skin, including the epidermis, dermoepidermal junction, dermis, hair follicles, blood vessels, and sweat ducts. OCT is a promising new noninvasive real-time imaging modality for investigation of skin morphology. In some cases it may be useful for diagnosis of skin disease. Because of its non-invasive character, the technique enables monitoring of inflammatory disease over time. Objective quantification of the efficacy and tolerance of topical treatment is also possible.