Analytical method development and validation of L-Carnitine L-Tartarate in Pharmaceutical Dosage forms (Multivitamin tablets) using non aqueous titration

Abstract

The   Non aqueous titration   method was developed for quantitave analysis of  L-  Carnitine L-Tartarate    in  multivitamin  tablets. The   Non aqueous titration method was carried out using 0.1  N  Perchloric acids. The   present   analytical    method   was validated according to ICH guidelines  (ICH,Q2(R1)).  The   calibration   curve   was  found    to   linear  with correlation coefficient   (r2=0.99995),  Bias   (-0.35)  in  the  range  of  50  to 150  %  of  standard solution. The   precision   and   recovery   were determined   and  all  the  parameter value found within acceptance  limit. The  value  for  both method  and intermediate  precision were found to 0.57 % and recovery  found  to 99.11 to 99.59 %.  The   validation parameter  study  was  method  precision,  intermediate   precision,   Linearity   and   recovery.  This is a   convenient, precise   and   rapid    accurate  method    for  the estimation  of   L-Carnitine  L-Tartarate  in  Bulk  and Pharmaceutical dosage forms (Multivitamin Tablets). Keywords: AIDS, Linearity, Correlation coefficient, Bias, Precision and Recovery