Exploring potential anti-inflammatory effects of medicinal cannabis

Abstract

Purpose: Inflammation is thought to play a key role in malignant disease and may play a significant part in the expression of cancer-related symptoms. Cannabidiol (CBD) is a bioactive compound in cannabis and is reported to have significant anti-inflammatory properties. Method: Serial C-reactive protein (CRP) levels were measured in all participants recruited to a randomised controlled trial of CBD versus placebo in patients with symptoms related to advanced cancer. A panel of inflammatory cytokines was measured over time in a subset of these patients. Results: There was no difference between the two arms in the trajectory of CRP or cytokine levels from baseline to day 28. Conclusion: We were unable to demonstrate an anti-inflammatory effect of CBD in cancer patients. Trial registration: ANZCTR 26180001220257, registered 20/07/2018.