Pseudohypoparathyroidism: A case report

Abstract

The first 3 cases of pseudohypoparathyroidism were reported by Albright (1) in 1942, and since that time approximately 23 cases have been recorded (2–12). Thus it is still a relatively new and uncommon condition. The syndrome presents the same clinical features as idiopathic or postoperative hypoparathyroidism, but additional findings are (a) lack of response to parathyroid hormone, (b) a short, stocky habitus with rounded facies, (c) calcinosis cutis, and (d) early closure of some of the metacarpals and metatarsals (2). Albright thought the condition represented failure of end-organ response as exemplified in the “Seabright-bantam syndrome,” in which the Seabright bantam, with a normal level of the male hormone, fails to produce normal male plumage. In pseudohypoparathyroidism the body fails to respond even to excessive amounts of the parathyroid hormone. In fact the lack of phosphorus diuresis after administration of parathyroid extract is given as one of the diagnostic tests (6). The following case is of interest, in view of the few reports in the medical literature to date. © 1954 by The Endocrine Society.