Chemical study, antioxidant capacity, and hypoglycemic activity of malva pseudolavatera webb & berthel and malva sylvestris l. (malvaceae), grown in ecuador

Abstract

Malva pseudolavatera and M. sylvestris (Malvaceae) are two species in great demand in Ecuador for their medicinal virtues. However, the chemical and biological information on M. psudolavatera is scarce. The present study aims to carry out a comparative chemical study of the antioxidant and hypoglycemic activities of the leaves of the species M. pseudolavatera and M. sylvestris to justify their traditional use. Extracts were made with 80% hydroalcoholic mixture from the leaves of M. sylvestris and M. pseudolavatera. The chemical composition was analyzed by Liquid chromatography coupled to mass spectrometry. The antioxidant capacity was performed by the Ferric Reducing Antioxidant Power, 2,2-diphenyl-1-picrylhydrazyl and 2,2'azino-bis(3-ethylbenzothiazoline-6-sulfonic acid techniques and the hypoglycemic activity in Wistar rats at the doses of 250, 500 and 1000 mg/kg, of the extracts, were evaluated. Liquid chromatography coupled to mass spectrometry analysis allowed the detection of similarities and differences in the chemical composition of both leaf extracts, the flavonoid gosipetin 3-O-β-D-glucopyranosyl-8-O-β-D-glucuronopyranoside, was found in both species and for M. pseudolavatera is reported for the first time. The extract of M. sylvestris showed antioxidant capacity and hypoglycemic activity, superior to the extract of M. pseudolavatera. The results of this research report for the first time the phenolic and flavonoid composition, as well as the antioxidant and hypoglycemic activity of the extracts of the leaves of M. pseudolavatera and its comparison with that of M. sylvestris for which there were previous reports.