Lead (Pb++) is a toxic agent that can exert adverse effects on the cardiac human health. Pb++ blocks the Ltype Ca++ channels. A decrease in L-type calcium current (ICaL) is an important mechanism favoring atrial fibrillation. It is important to study the electrophysiological Pb++ effects on the atrial action potential in healthy people and those with AF. For this, we study the consequences of Pb++ on action potential, under normal and atrial fibrillation condition using in silico models. Our results suggest that Pb++ blocks ICaL current in a fraction greater as the concentration increases, resulting in an action potential duration shortening, Pb++ has a greater action potential duration effect on control conditions. To our knowledge, this is the first work that has developed mathematical models of Pb++ effect on ICaLcurrent to study its effect on human atrial action potential.
CITATION STYLE
Tobón, C., Pachajoa, D., Ugarte, J. P., & Saiz, J. (2017). Lead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study. In IFMBE Proceedings (Vol. 60, pp. 66–69). Springer Verlag. https://doi.org/10.1007/978-981-10-4086-3_17
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