Rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated alkenes

Abstract

(Figure Presented) One for the Rh(oad): The first rhodiumcatalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod = 1,5-cyclooctadiene, Cy = cyclohexyl). A variety of 2-methylpyrrolidines have been synthesized with high enantioselectivities. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.