Updates on the Molecular Genetics of Colorectal Cancer

Abstract

Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Although definitive therapies for advanced disease are still lacking, rapid progress has been made in the last decade in understanding the molecular mechanisms underlying CRC tumorigenesis and progression. In this review, we summarize the most recent findings in the molecular genetics of CRC with a focus on gene mutations and epigenetic changes that were identified in CRC patients.