Efficient synthesis of pyrrolo[2,1-a]isoquinoline and pyrrolo[1,2-a] quinoline derivatives via one-pot two-step metal-catalyzed three-component reactions

Abstract

A sequential one-pot two-step reaction for efficient synthesis of pyrrolo[2,1-a]isoquinoline and pyrrolo[1,2-a]quinoline derivatives in good yields has been successfully developed. The reaction included firstly Cu-catalyzed three-component reaction of isoquinoline (quinoline), acetylenedicarboxylate and alkynylbenzene and then Pd-catalyzed intramolecular C(sp)-C(sp 2) coupling reaction of initially formed 1-alkenyl-2-alkynyl-1,2-dihydroisoquinoline (1,2-dihydroquinoline). © 2012 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.