Nailfold capillary morphology and platelet function in patients with exfoliative glaucoma

6Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Purpose The purpose of the present study was to evaluate the nailfold capillary morphological features in patients with exfoliative glaucoma (XFG) and compare them with those pertaining to primary open-angle glaucoma (POAG), normal controls and subjects with exfoliation syndrome (XFS). The second purpose was to investigate all parameters related to platelet function on the hemogram, including the platelet count (PLT), the mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in patients with XFG. These parameters were subsequently compared with those belonging to normal controls, POAG and XFS subjects. Methods This case control study involved 152 consecutive patients that were examined at the Glaucoma Department of Clinic for Eye Diseases, Clinical Centre of Serbia, as the referral center for glaucoma in Serbia, between June 2016 and December 2017. Results Regarding capillaroscopic characteristics, statistically significant difference was found in capillary diameter and tortuosity between the XFG and POAG group (p = 0.050 and p = 0.035) and the XFG and NC group (p = 0.003 and p = 0.044), as well as in the distribution of capillary loops and avascular zones between the XFG and NC group (p = 0.014 and p = 0.004). The subjects with XFG had lower PLT values compared to POAG patients (p = 0.022). Conclusions In conclusion, to the best of our knowledge, this study marks the first attempt to evaluate capillary morphology as well as to investigate all parameters related to platelet function on the hemogram, in patients with newly diagnosed XFG. Our findings revealed nailfold capillary morphological vascular changes in XFG patients. The subjects with XFG had lower PLT values and a higher MPV serum parameter compared to normal controls and patients with POAG. Further research in this field should therefore aim to evaluate the consequences of the aforementioned microvascular abnormalities in patients with XFG.

References Powered by Scopus

Platelets in inflammation and atherogenesis

1197Citations
N/AReaders
Get full text

Mean platelet volume: A link between thrombosis and inflammation?

1024Citations
N/AReaders
Get full text

Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta-analysis

823Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages

4Citations
N/AReaders
Get full text

Nailfold videocapillaroscopy in patients with central serous chorioretinopathy and its relationship to morphological and functional findings

3Citations
N/AReaders
Get full text

Results of Nailfold Videocapillaroscopy in Patients with Pseudoexfoliative Glaucoma

2Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Maric, V., Grgurevic, A., Cirkovic, A., Stankovic, S., Marjanovic, I., Milovanovic, J., … Bozic, M. (2019). Nailfold capillary morphology and platelet function in patients with exfoliative glaucoma. PLoS ONE, 14(7). https://doi.org/10.1371/journal.pone.0219505

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

64%

Professor / Associate Prof. 3

27%

Researcher 1

9%

Readers' Discipline

Tooltip

Medicine and Dentistry 7

70%

Agricultural and Biological Sciences 1

10%

Immunology and Microbiology 1

10%

Chemistry 1

10%

Save time finding and organizing research with Mendeley

Sign up for free