Anti-phosphoryl choline and hs-CRP in serum of atherosclerosis cardiovascular patient with chronic periodontitis

Abstract

Background: Periodontitis and Atherosclerosis Cardiovascular disease are chronic inflammatory diseases which are highly prevalent. Over the last two decades, the amount of evidence corroborating an association between dental plaque bacteria and coronary diseases that develop as a result of atherosclerosis has increased. The aim of study: was to evaluate the periodontal health status in study groups (Atherosclerotic cardiovascular disease patients with chronic periodontitis (ATH+CP) and patients having chronic periodontitis (CP)), to investigate the serum level of antiphosphorylcholine antibody-IgG(AntiPC IgG), and the systemic level of inflammatory marker of cardiovascular diseases like high sensitivity C-reactive protein (hs-CRP) in chronic periodontitis with and without atherosclerosis cardiovascular disease as well as to examine the relationships between these mediators and clinical periodontal parameters. Material and Methods: Blood samples were collected from sixty patients (30 CP patients and 30 CP+ATH patients) and from 25 apparently healthy volunteers were enrolled in this study. Periodontal parameters used in this study were plaque index (P.I), gingival index (G.I), bleeding on probing(BOP), probing pocket depth(PPD) and clinical attachment level (CAL) and Serum levels of Anti-PC IgG was estimate by enzyme linked immunosorbent assays (ELISA) and hs-CRP was estimate by immunoturbidimetric. Results: The current data revealed a significant elevation (p<0.01) in median level of hs-CRP in CP group and CP+ ATH group in comparison to that in healthy control, moreover, the comparison between two groups of patients showed significant differences between two groups (p<0.05).Whereas the serum level of antiphosphorylcholine-IgG was not observed significant differences between study groups (p>0.05) except for CP group when compared to control group (p≤0.05).Moreover, in regards to the correlation between serum antiphosphorylcholine –IgG and hs-CRP, and clinical periodontal parameters, did not show any correlation with clinical parameters of periodontitis (p>0.05). Conclusion: inflammatory mediator (hs-CRP) may increase inflammatory activity in atherosclerotic lesions and potentially increasing the risk for cardiovascular events in CP+ATH, furthermore, about the effect of Anti-PC IgG in ATH +CP group, further studies are needed to obtain more understanding result.