Pathology of Lymphoreticular Tissues

Abstract

Hematopathology is a discipline in which the routine methods of clinical and morphologic analysis are interwoven with routine laboratory as well various ancillary techniques for diagnosis and management of hematolymphoid lesions. Such lesions broadly may be divided into non-neoplastic (like viral, tubercular, autoimmune, drug induced) and neoplastic. Neoplastic lesions involving nodes could be hematolymphoid or non-hematolymphoid neoplasms. Scope of this chapter is hematolymphoid neoplasms (HLN) as defined by the WHO 2017 Classification of HLN and others [1–3]. Here we discuss the morphology of normal lymphoreticular tissues (primarily lymph nodes, bone marrow trephine biopsy, spleen, and thymus) followed by an approach to diagnosis and subtyping of HLN based on morphology and various ancillary techniques, primarily immunohistochemistry (IHC) (Figs. 16.1, 16.2, 16.3, and 16.4). Bone marrow aspirate is not a part of the scope of this chapter.