Complexation of Several Drugs with Water-Soluble Cyclodextrin Polymer

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Abstract

The complex-forming abilities of a water-soluble β-cyclodextrin-epichlorohydrin polymer (CDPS) and two different molecular weight fractions of CDPS were studied and compared with those of β-cyclodextrin (β-CyD) and dimethyl-β-cyclodextrin (DM-β-CyD). CDPS was separated into two main fractions by gel chromatography. CDPS and its fractions formed inclusion compounds with several drugs and these complexes were readily soluble. The low-molecular-weight fraction formed rather stable complexes with small guest molecules. The high-molecular-weight fraction was found to be more efficient in binding larger substrates. © 1987, The Pharmaceutical Society of Japan. All rights reserved.

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Szeman, J., Ueda, H., Machida, Y., Nagai, T., Szejtli, J., & Fenyvesl, E. (1987). Complexation of Several Drugs with Water-Soluble Cyclodextrin Polymer. Chemical and Pharmaceutical Bulletin, 35(1), 282–288. https://doi.org/10.1248/cpb.35.282

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