In vitro activity of 3-triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium

11Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

Among 230 target-synthesized indole-based compounds, seven 3-triazenoindoles showed MICs of 0.2 to 0.5 μg/ml against Mycobacterium tuberculosis strain H37Rv and isoniazid-resistant human isolate CN-40. The TU112 compound was active also against a dormant form of M. tuberculosis. Some of these triazenoindoles were active against Mycobacterium avium, with MICs of 0.05 to 0.5 μg/ml. The selectivity indices (SI) for M. tuberculosis and M. avium were significantly higher than 10, making these compounds acceptable for the next testing step.

Cite

CITATION STYLE

APA

Nikonenko, B. V., Kornienko, A., Majorov, K., Ivanov, P., Kondratieva, T., Korotetskaya, M., … Velezheva, V. (2016). In vitro activity of 3-triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrobial Agents and Chemotherapy, 60(10), 6422–6424. https://doi.org/10.1128/AAC.00998-16

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free