Among 230 target-synthesized indole-based compounds, seven 3-triazenoindoles showed MICs of 0.2 to 0.5 μg/ml against Mycobacterium tuberculosis strain H37Rv and isoniazid-resistant human isolate CN-40. The TU112 compound was active also against a dormant form of M. tuberculosis. Some of these triazenoindoles were active against Mycobacterium avium, with MICs of 0.05 to 0.5 μg/ml. The selectivity indices (SI) for M. tuberculosis and M. avium were significantly higher than 10, making these compounds acceptable for the next testing step.
CITATION STYLE
Nikonenko, B. V., Kornienko, A., Majorov, K., Ivanov, P., Kondratieva, T., Korotetskaya, M., … Velezheva, V. (2016). In vitro activity of 3-triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrobial Agents and Chemotherapy, 60(10), 6422–6424. https://doi.org/10.1128/AAC.00998-16
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