microRNAs (miRNAs) are emerging as novel biological targets for medicinal chemists to develop chemical tools for intracellular regulation. In this context, the discovery of small-molecule drugs targeting specific miRNAs and modulating their production or function represents a very promising approach that could be further developed for targeted therapy in miRNA-related pathologies. Here, we describe the design of multimodal small molecules as RNA ligands targeting DICER-mediated miRNA maturation. The synthesis and the biochemical evaluation as ligands of stem-loop-structured precursor microRNAs (pre-miRNAs) are reported.
CITATION STYLE
Vo, D. D., & Duca, M. (2017). Design of multimodal small molecules targeting miRNAs biogenesis: Synthesis and in vitro evaluation. In Methods in Molecular Biology (Vol. 1517, pp. 137–154). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6563-2_10
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