Nanoscale characterization of hydroxyapatite particles by electron microscopy

Abstract

Owing to its chemical similarity to the mineral phase of human bone and to its biological performance, synthetic hydroxyapatite (HA, Ca10(PO4)6(OH)2) has long been recognized as an important bone substitute material in orthopaedics, dentistry and artificial implants. HA ceramics have also been studied as drug delivery systems components where an appropriate porosity for ensuring a high ability forcarryingand delivering drugs in a controlled manner is required. For some emerging applications demanding nanoscale structured systems endowed with novel potentialities HA nanoparticles may be addressed as alternative components ensuring a large surface area for adsorbing the pharmacological substance of interest. Moreover particle porosity may offer new possibilities for drug or nutrient delivery, or for biocompatible and bioresobable structural reinforcements in osteologic implants, coatings and adhesives. Mesostructured porous calcium phosphate based systems have been synthesized at macro- and micro-scale, but well established methods for the specific synthesis of porous HA nanoparticles have not been reported so far. Yao et al. reported a successful synthesis of HA mesoporous micron-sized rods 0.5-1 m in length and 50-100 nm in thickness but having low porosity. A new synthesis challenge for producing nano-sized particles of high surface area and having ordered mesopores is thus addressed. © 2008 Microscopy Society of America.