Background: Fluralaner (Bravecto™; Merck/MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea and tick control after a single oral dose. Milbemycin oxime and praziquantel are routinely used to control Dirofilaria immitis and intestinal worm infections in dogs. The safety of concurrent use of fluralaner and a commercially available milbemycin oxime plus praziquantel combination tablet, in particular with regard to gastrointestinal symptoms, was investigated using oral doses at or above the maximum recommended rates. Findings: Some minor and transient clinical findings were observed during the study period; however, none of these was considered to be related to concurrent treatment with fluralaner and milbemycin oxime plus praziquantel, or to the use of either product alone. Conclusions: Concurrent treatment with fluralaner, milbemycin oxime and praziquantel is well tolerated in dogs.
CITATION STYLE
Walther, F. M., Fisara, P., Allan, M. J., Roepke, R. K. A., & Nuernberger, M. C. (2014). Safety of concurrent treatment of dogs with fluralaner (BravectoTM) and milbemycin oxime - Praziquantel. Parasites and Vectors, 7(1). https://doi.org/10.1186/s13071-014-0481-y
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