Double-membrane-bound nucleus is the major organelle of every metazoan cell, which controls various nuclear processes like chromatin maintenance, DNA replication, transcription and nucleoskeleton-cytoskeleton coupling. Nuclear homeostasis depends on the integrity of nuclear membrane and associated proteins. Lamins, underlying the inner nuclear membrane (INM), play a crucial role in maintaining nuclear homeostasis. In this review, we have focussed on the disruption of nuclear homeostasis due to lamin A/C mutation which produces a plethora of diseases, termed as laminopathies.
CITATION STYLE
Dutta, S., Bhattacharyya, M., & Sengupta, K. (2018). Changes in the nuclear envelope in laminopathies. In Advances in Experimental Medicine and Biology (Vol. 1112, pp. 31–38). Springer New York LLC. https://doi.org/10.1007/978-981-13-3065-0_3
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