Research Progress on Silver-Catalyzed Decarboxylative Coupling Reaction

Abstract

Transition-metal-catalyzed decarboxylative cross-coupling reactions have been well developed as efficient synthetic methods in organic synthesis. Herein the new application of silver-catalyzed decarboxylation in Hunsdiecker-type halogenation, carbon-carbon bond formation, carbon-heteratom bond formation and C-H bond functionalization reaction is discussed. The recent progress in silver-catalyzed decarboxylative coupling reaction with aliphatic carboxylic acids, α-keto acids and aryl carboxylic acid is reviewed. With the assistance of peroxides, selective decarboxylative coupling reaction could be proceeded via free-radical process by silver catalysis. The controlled free-radical transformation is operational simplification without the exclusion of water and oxygen under mild conditions.