The use of radiolabeled molecules allows a drug and its labeled metabolites to be followed throughout the body and excreta over time. The radioactivity concentration can be tracked in blood and plasma as well as in tissues. Whether the drug with its specific radioactivity administered to the body is completely captured can be proven by calculating the so-called mass balance.
CITATION STYLE
Krone, V. (2013). Absorption: In vivo tests (radiolabeled). In Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, Second Edition (pp. 799–834). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-25240-2_33
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