The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and dna replicationcoupled nucleosome assembly in budding yeast

Abstract

Background: Genome stability is maintained in part by chromatin structure and checkpoint factors. Results: Yeast cells harboring mutations in the Ddc1-Mec3-Rad17 checkpoint complex exhibit synthetic phenotypes with histone chaperone mutants. Conclusion: The Ddc1-Mec3-Rad17 complex regulates nucleosome assembly. Significance: Checkpoint factors and histone chaperones coordinate to maintain genome integrity.© 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.