Understanding the complex interplay between cells and their biomechanics and how the interplay is influenced by the extracellular microenvironment, as well as how the transforming potential of a tissue from a benign to a cancerous one is related to the dynamics of both the cell and its surroundings, holds promise for the development of targeted translational therapies. This review provides a comprehensive overview of atomic force microscopy-based technology and its applications for identification of cellular progression to a cancerous phenotype. The review also offers insights into the advancements that are required for the next user-controlled tool to allow for the identification of early cell transformation and thus potentially lead to improved therapeutic outcomes.
CITATION STYLE
Dong, C., Hu, X., & Dinu, C. Z. (2016, May 17). Current status and perspectives in atomic force microscopy-based identification of cellular transformation. International Journal of Nanomedicine. Dove Medical Press Ltd. https://doi.org/10.2147/IJN.S103501
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