C-19393 S2and H2, new carbapenem antibiotics IV. Inhibitory activity against β-lactamases

Abstract

New carbapenem antibiotics, C-19393 S2and H2, have been found to be potent and broad-spectrum inhibitors of β-lactamases. Among 11 types of β-lactamases tested, those from Escherichia coli (plasmid-bearing), Klebsiella pneumoniae, Proteus vulgaris, Serratia marcescens and Bacteroicles fragilis were especially sensitive. They also inhibited cephalosporinases insensitive to clavulanic acid. The inhibition by C-19393 S2and H2was of progressive type, except for the inhibition of E. coli enzyme (plasmid-mediated type I) by C-19393 H2. The inhibition of E. coli β-lactamase by C-19393 S2was irreversible, while that by C-19393 H2 was reversible. © 1981, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.