Expansion of genes that encode MHC class I molecules in cyprinid fishes.

  • Okamura K
  • Nakanishi T
  • Kurosawa Y
  • et al.
46Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

We have analyzed the genomic genes and the mRNA that encode MHC class I molecules in cyprinid fishes, namely, the ginbuna crucian carp (Carassius auratus langsdorfii) and the carp (Cyprinus carpio). The presence of several distinct class I genes was revealed in the genome of cyprinid fishes, and distinct class I genes that are expressed in carp cells were identified. The sequences of the alpha 3 domain of these class I genes are relatively well conserved, whereas the sequences of the respective alpha 1 and alpha 2 domains have diverged from one another. A comparison of the sequences expressed in carp with the sequences of the human classical class I molecules revealed that several amino acids in the peptide-binding region, including those that have been proposed to interact with antigenic peptide termini, are highly conserved. The present study demonstrated a dynamic expansion of the genes that encode MHC class I molecules in teleost fish whose ancestor branched off from the vertebrate line leading to mammals more than 400 million years ago.

Cite

CITATION STYLE

APA

Okamura, K., Nakanishi, T., Kurosawa, Y., & Hashimoto, K. (1993). Expansion of genes that encode MHC class I molecules in cyprinid fishes. The Journal of Immunology, 151(1), 188–200. https://doi.org/10.4049/jimmunol.151.1.188

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free