Inhibition with lactoferrin of in vitro infection with human herpes VIRUS

Abstract

Human lactoferrin (hLF) as well as bovine lactoferrin (bLF) inhibited infection of tissue culture cells with human cytomegalovirus (HCMV) and human herpes simplex virus-1 (HSV-1). the addition of lactoferrin (LF) inhibited both in vitro infection and replication of HCMV and HSV-1 in human embryo lung host cells. the maximum inhibition by more than six exponentials of TCID50 for HCMV and four exponentials for HSV-1 was obtained at a concentration in a range from 0.5 to 1 mg of LF per ml of medium. © 1994, National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee. All rights reserved.