A novel classification of lung cancer into molecular subtypes

99Citations
Citations of this article
168Readers
Mendeley users who have this article in their library.

Abstract

The remarkably heterogeneous nature of lung cancer has become more apparent over the last decade. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. The discovery of multiple molecular mechanisms underlying the development, progression, and prognosis of lung cancer, however, has created new opportunities for targeted therapy and improved outcome. In this paper, we define "molecular subtypes" of lung cancer based on specific actionable genetic aberrations. Each subtype is associated with molecular tests that define the subtype and drugs that may potentially treat it. We hope this paper will be a useful guide to clinicians and researchers alike by assisting in therapy decision making and acting as a platform for further study. In this new era of cancer treatment, the 'one-size-fits-all' paradigm is being forcibly pushed aside-allowing for more effective, personalized oncologic care to emerge.

Cite

CITATION STYLE

APA

West, L., Vidwans, S. J., Campbell, N. P., Shrager, J., Simon, G. R., Bueno, R., … Salgia, R. (2012). A novel classification of lung cancer into molecular subtypes. PLoS ONE, 7(2). https://doi.org/10.1371/journal.pone.0031906

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free