Ameliorating Effects of Delphinol®, Anthocyanin Standardized Maqui Berry Extract, on Skin Brightness and Redness in Japanese Females: A Randomized Double-Blind Placebo-Controlled Pilot Study

Abstract

Maqui berries are wildly grown or cultivated in the Patagonian region in Chile. The berries contain large amounts of anthocyanins, especially delphi-nidin glycosides, which are strong anti-oxidants. We previously reported that standardized maqui berry extract, which contained lots of anthocyanins, has ameliorative effects against dry eyes and visible light-induced photoreceptor cell damage. However, the influence of maqui berry extract on the human skin has not been evaluated even though many skin troubles are related to active oxygen species. Therefore, we conducted a randomized double-blind placebo-controlled pilot study with Delphinol®, a maqui berry extract standardized for anthocyanins, especially delphinidins and cyanidins, in healthy Japanese female subjects. Capsules containing Delphinol® (60 mg) or placebo were orally administered to subjects aged 27 to 57 years old for eight weeks. Skin conditions [pigmentation, redness, skin tone, wrinkles, texture, oil content , water content, trans epidermal water loss (TEWL), collagen score, der-mal thickness, and elasticity] were measured before and after intervention. In the Delphinol® group, the saturation significantly increased after eight weeks and reddish spots significantly decreased after four weeks of intake. The col-lagen score, which decreases with age, slightly increased with age by Delphi-nol® ingestion for eight weeks. Thus, the anthocyanin-standardized maqui berry extract Delphinol® increased skin brightness and collagen content, and improved facial skin redness. This study suggests that the daily oral intake of maqui berry extract can help maintain a healthy facial condition.