:NBuLi-promoted anti -Markovnikov selective hydroboration of unactivated alkenes and internal alkynes

Abstract

An efficient and general nBuLi-promoted anti-Markovnikov selective hydroboration of various α-alkenes, 1,1-disubstituted alkenes and internal alkynes with pinacolborane for the synthesis of alkylboronic esters is described. This protocol features easy accessibility of catalysts and substrates, a broad substrate scope, and simple operation as well as scale-up ability.