Mulberroside A, a glycosylated stilbene, was isolated and identified from the ethanol extract of the roots of Morus alba. Oxyresveratrol, the aglycone of mulberroside A, was produced by enzymatic hydrolysis of mulberroside A using the commercial enzyme Pectinex®. Mulberroside A and oxyresveratrol showed inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 and 0.49 μM, respectively. The tyrosinase inhibitory activity of oxyresveratrol was thus approximately 110-fold higher than that of mulberroside A. Inhibition kinetics showed mulberroside A to be a competitive inhibitor of mushroom tyrosinase with L-tyrosine and L-DOPA as substrate. Oxyresveratrol showed mixed inhibition and noncompetitive inhibition against L-tyrosine and L-DOPA, respectively, as substrate. The results indicate that the tyrosinase inhibitory activity of mulberroside A was greatly enhanced by the bioconversion process. © Society for Industrial Microbiology 2010.
CITATION STYLE
Kim, J. K., Kim, M., Cho, S. G., Kim, M. K., Kim, S. W., & Lim, Y. H. (2010). Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition. Journal of Industrial Microbiology and Biotechnology, 37(6), 631–637. https://doi.org/10.1007/s10295-010-0722-9
Mendeley helps you to discover research relevant for your work.