Structure of alahopcin (nourseimycin), a new dipeptide antibiotic

Abstract

The structure of alahopcin (nourseimycin) (1), a new dipeptide antibiotic isolated from Slreptomyces, has been established to be (2S,3R)-2-[(L-alanyl)amino]-4-formyl-3-(hydroxy-aminocarbonyl)butyric acid. 1 exists in two cyclic hemiacetal type tautomers formed by intramolecular ring closure between the hydroxyamino group and the formyl group in aqueous solution. The structure of the new weakly acidic amino acid (2), a constituent of 1, is revealed to be (2S,3R)-2-amino-4-formyl-3-(hydroxyaminocarbonyI)butyric acid, and 2 also exists in two cyclic hemiacetal type tautomers in aqueous solution. © 1985, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.