Donor Cell Myeloid Sarcoma in an Umbilical Cord Transplant Patient: A Case Report and a Review of the Literature

  • Hayes C
  • Petersen B
  • Malone A
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Abstract

Donor cell leukemia (DCL) represents a rare complication of allogeneic transplantation. The precise incidence remains unclear, though it may be higher following umbilical cord blood transplants. Here, we present an unusual case of a patient with B-ALL who presented with a donor derived myeloid sarcoma of the heart following a double cord blood transplant. To our knowledge, it is the first case of sarcomatous or chloromatous presentation of DCL following a UCBT.

Figures

  • Figure 1: EKG with T-wave inversions in the lateral leads V3–V5 as denoted by arrows.
  • Figure 2: Chest CT with circumferential pericardial and nodular soft tissue densities posterior to the heart as denoted by red arrows.
  • Figure 3: (a)H&E, low power. (b)H&E, high power. (c)Myeloperoxidase focal positivity. (d) CD43 commonly expressed inmyeloid sarcoma. (e) CD34 (marker of immaturity). (f) CD117 focal+ (expressed in immature myeloid cells). (g) CD68 weak+ (monocytic/histiocytic markers). (h) CD163 focal+ (monocytic/histiocytic marker).

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APA

Hayes, C., Petersen, B., & Malone, A. (2015). Donor Cell Myeloid Sarcoma in an Umbilical Cord Transplant Patient: A Case Report and a Review of the Literature. Case Reports in Hematology, 2015, 1–4. https://doi.org/10.1155/2015/186869

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