Peptide Vaccine: Overview

Abstract

"Peptide antigens are presented by class I HLA molecules and have been studied for use in cancer vaccines. Short peptides from 8 to 11 amino acids have been able to elicit immune responses in both animal and human studies historically, although none have been approved in the clinic. More recently, long peptides, phosphopeptides, helper peptides, hybrid peptides and peptide cocktails are being explored for use in vaccine therapies of cancer. Antigenic peptides have been found for every cancer type and the peptide vaccines have been tested in nearly all major cancer types. A few of the most important peptide vaccine studies are highlighted in this overview".