Molecular mechanism of replication and transcription of the influenza virus genome and host factors

Abstract

The genome of influenza A virus is a set of eight segmented- and single-stranded RNAs. A basic transcription and replication unit is the genome complexed with viral RNA-dependent RNA polymerases and nucleoprotein (NP). For the efficient transcription and replication of the genome, not only viral factors but also host cell-derived factors are required. Although receptor and protease molecules play important roles in infection and pathogenicity, it is also possible that host factors involved in the virus genome function determine these. PB2, for instance, is reported to be a possible candidate for determination of the host range of avian influenza viruses. Here we summarize recent progresses in the molecular mechanism of the influenza virus genome transcription and replication and discuss the involvement of host factors in these processes.